mirror of
https://gitee.com/coder-xiaomo/leetcode-problemset
synced 2025-09-05 15:31:43 +08:00
131 lines
5.1 KiB
HTML
131 lines
5.1 KiB
HTML
<p>Table: <code>Samples</code></p>
|
|
|
|
<pre>
|
|
+----------------+---------+
|
|
| Column Name | Type |
|
|
+----------------+---------+
|
|
| sample_id | int |
|
|
| dna_sequence | varchar |
|
|
| species | varchar |
|
|
+----------------+---------+
|
|
sample_id is the unique key for this table.
|
|
Each row contains a DNA sequence represented as a string of characters (A, T, G, C) and the species it was collected from.
|
|
</pre>
|
|
|
|
<p>Biologists are studying basic patterns in DNA sequences. Write a solution to identify <code>sample_id</code> with the following patterns:</p>
|
|
|
|
<ul>
|
|
<li>Sequences that <strong>start</strong> with <strong>ATG</strong> (a common <strong>start codon</strong>)</li>
|
|
<li>Sequences that <strong>end</strong> with either <strong>TAA</strong>, <strong>TAG</strong>, or <strong>TGA</strong> (<strong>stop codons</strong>)</li>
|
|
<li>Sequences containing the motif <strong>ATAT</strong> (a simple repeated pattern)</li>
|
|
<li>Sequences that have <strong>at least</strong> <code>3</code> <strong>consecutive</strong> <strong>G</strong> (like <strong>GGG</strong> or <strong>GGGG</strong>)</li>
|
|
</ul>
|
|
|
|
<p>Return <em>the result table ordered by </em><em>sample_id in <strong>ascending</strong> order</em>.</p>
|
|
|
|
<p>The result format is in the following example.</p>
|
|
|
|
<p> </p>
|
|
<p><strong class="example">Example:</strong></p>
|
|
|
|
<div class="example-block">
|
|
<p><strong>Input:</strong></p>
|
|
|
|
<p>Samples table:</p>
|
|
|
|
<pre class="example-io">
|
|
+-----------+------------------+-----------+
|
|
| sample_id | dna_sequence | species |
|
|
+-----------+------------------+-----------+
|
|
| 1 | ATGCTAGCTAGCTAA | Human |
|
|
| 2 | GGGTCAATCATC | Human |
|
|
| 3 | ATATATCGTAGCTA | Human |
|
|
| 4 | ATGGGGTCATCATAA | Mouse |
|
|
| 5 | TCAGTCAGTCAG | Mouse |
|
|
| 6 | ATATCGCGCTAG | Zebrafish |
|
|
| 7 | CGTATGCGTCGTA | Zebrafish |
|
|
+-----------+------------------+-----------+
|
|
</pre>
|
|
|
|
<p><strong>Output:</strong></p>
|
|
|
|
<pre class="example-io">
|
|
+-----------+------------------+-------------+-------------+------------+------------+------------+
|
|
| sample_id | dna_sequence | species | has_start | has_stop | has_atat | has_ggg |
|
|
+-----------+------------------+-------------+-------------+------------+------------+------------+
|
|
| 1 | ATGCTAGCTAGCTAA | Human | 1 | 1 | 0 | 0 |
|
|
| 2 | GGGTCAATCATC | Human | 0 | 0 | 0 | 1 |
|
|
| 3 | ATATATCGTAGCTA | Human | 0 | 0 | 1 | 0 |
|
|
| 4 | ATGGGGTCATCATAA | Mouse | 1 | 1 | 0 | 1 |
|
|
| 5 | TCAGTCAGTCAG | Mouse | 0 | 0 | 0 | 0 |
|
|
| 6 | ATATCGCGCTAG | Zebrafish | 0 | 1 | 1 | 0 |
|
|
| 7 | CGTATGCGTCGTA | Zebrafish | 0 | 0 | 0 | 0 |
|
|
+-----------+------------------+-------------+-------------+------------+------------+------------+
|
|
</pre>
|
|
|
|
<p><strong>Explanation:</strong></p>
|
|
|
|
<ul>
|
|
<li>Sample 1 (ATGCTAGCTAGCTAA):
|
|
<ul>
|
|
<li>Starts with ATG (has_start = 1)</li>
|
|
<li>Ends with TAA (has_stop = 1)</li>
|
|
<li>Does not contain ATAT (has_atat = 0)</li>
|
|
<li>Does not contain at least 3 consecutive 'G's (has_ggg = 0)</li>
|
|
</ul>
|
|
</li>
|
|
<li>Sample 2 (GGGTCAATCATC):
|
|
<ul>
|
|
<li>Does not start with ATG (has_start = 0)</li>
|
|
<li>Does not end with TAA, TAG, or TGA (has_stop = 0)</li>
|
|
<li>Does not contain ATAT (has_atat = 0)</li>
|
|
<li>Contains GGG (has_ggg = 1)</li>
|
|
</ul>
|
|
</li>
|
|
<li>Sample 3 (ATATATCGTAGCTA):
|
|
<ul>
|
|
<li>Does not start with ATG (has_start = 0)</li>
|
|
<li>Does not end with TAA, TAG, or TGA (has_stop = 0)</li>
|
|
<li>Contains ATAT (has_atat = 1)</li>
|
|
<li>Does not contain at least 3 consecutive 'G's (has_ggg = 0)</li>
|
|
</ul>
|
|
</li>
|
|
<li>Sample 4 (ATGGGGTCATCATAA):
|
|
<ul>
|
|
<li>Starts with ATG (has_start = 1)</li>
|
|
<li>Ends with TAA (has_stop = 1)</li>
|
|
<li>Does not contain ATAT (has_atat = 0)</li>
|
|
<li>Contains GGGG (has_ggg = 1)</li>
|
|
</ul>
|
|
</li>
|
|
<li>Sample 5 (TCAGTCAGTCAG):
|
|
<ul>
|
|
<li>Does not match any patterns (all fields = 0)</li>
|
|
</ul>
|
|
</li>
|
|
<li>Sample 6 (ATATCGCGCTAG):
|
|
<ul>
|
|
<li>Does not start with ATG (has_start = 0)</li>
|
|
<li>Ends with TAG (has_stop = 1)</li>
|
|
<li>Starts with ATAT (has_atat = 1)</li>
|
|
<li>Does not contain at least 3 consecutive 'G's (has_ggg = 0)</li>
|
|
</ul>
|
|
</li>
|
|
<li>Sample 7 (CGTATGCGTCGTA):
|
|
<ul>
|
|
<li>Does not start with ATG (has_start = 0)</li>
|
|
<li>Does not end with TAA, "TAG", or "TGA" (has_stop = 0)</li>
|
|
<li>Does not contain ATAT (has_atat = 0)</li>
|
|
<li>Does not contain at least 3 consecutive 'G's (has_ggg = 0)</li>
|
|
</ul>
|
|
</li>
|
|
</ul>
|
|
|
|
<p><strong>Note:</strong></p>
|
|
|
|
<ul>
|
|
<li>The result is ordered by sample_id in ascending order</li>
|
|
<li>For each pattern, 1 indicates the pattern is present and 0 indicates it is not present</li>
|
|
</ul>
|
|
</div>
|